Key Points

Primary hyperparathyroidism (PHPT) is characterized by elevated plasma levels of parathyroid hormone (PTH) and calcium with reduced plasma phosphate. PHPT is the third most frequently diagnosed endocrine disorder. It is a silent health problem in the elderly until it becomes apparent with cognitive and physical consequences, for example, mental status change, severe constipation, and fracture.


Primary Hyperparathyroidism Handout


Adami, S., Marcocci, C., & Gatti, D.. Epidemiology of primary hyperparathyroidism in Europe. Journal of Bone and Mineral Research 2002;Suppl 2:N18-23.

Bilezikian, J., Khan, A., Potts, T. Jr, (2009). Third International Workshop Asymptomatic Primary Hyperthyroidism. Guidelines for the management of asymptomatic primary hyperparathyroidism: Summary statement. Journal of Clinical Endocrinology & Metabolism; 94:335-339.

Kim, L., Whittier Krause, M., & Kantorovich. (2012). Primary Hyperparathyroidism. Medscape Reference Drugs, Diseases & Procedures. Retrieved from